Developmental Changes in Pharmacokinetics and Pharmacodynamics

Pharmacokinetics/ Pharmacodynamics

Topiramate: pharmacokinetics and pharmacodynamics.

Topiramate is a structurally novel anti-epileptic drug with at least 3 postulated mechanisms of action including: 1) potentiation of GABA responses, 2) impairment of AMPA/kainate glutamate receptors and 3) suppression of high frequency action potential firing. It has a favourable pharmacokinetic profile with rapid absorption, good bio-availability, linear pharmacokinetics, relatively long half-...

Macrolides: pharmacokinetics and pharmacodynamics.

Three pharmacokinetic/pharmacodynamic parameters--(i) the peak concentration to the minimum inhibitory concentration ratio (C(max)/MIC); (ii) the area under the concentration-time curve to MIC ratio (AUC(24h)/MIC); and (iii) the time the concentration exceeds the MIC (T>MIC)--are important predictors of the clinical efficacy of antibiotics. For antibiotics with pronounced concentration-dependen...

Antifungal pharmacokinetics and pharmacodynamics.

Successful treatment of infectious diseases requires choice of the most suitable antimicrobial agent, comprising consideration of drug pharmacokinetics (PK), including penetration into infection site, pathogen susceptibility, optimal route of drug administration, drug dose, frequency of administration, duration of therapy, and drug toxicity. Antimicrobial pharmacokinetic/pharmacodynamic (PK/PD)...

Pharmacokinetics , Pharmacodynamics , and Pharmacogenomics

ABBREVIATIONS IN THIS CHAPTER AKI Acute kidney injury Clh Hepatic clearance Clint Intrinsic clearance Cmax Maximum concentration CYP450 Cytochrome P450 Eh Hepatic extraction efficiency or ratio Fu Fraction unbound GFR Glomerular filtration rate KDIGO Kidney Disease: Improving Global Outcomes LNPEP Leucyl/cystinyl aminopeptidase PCI Percutaneous coronary intervention PD Pharmacodynamics PGx Phar...